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In contrast, the NEH2 domain mediates interaction with Keap1, a cytoplastic repressor that facilitates NRF2 ubiquitination and proteasomal degradation under basal conditions (Tong et al., 2006)

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It could be argued that intervening in OS can be useful in the clinical management of infertile couples: in fact, as clearly shown in the present review, OS can have a negative effect on sexual health, reproductive function, and psychological status